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Dilated aortic root

MedGen UID:
334633
•Concept ID:
C1842881
•
Finding

Professional guidelines

PubMed

A case of G1013R FBN1 mutation: A potential genotype-phenotype correlation in severe Marfan syndrome.
Willis BR, Lee M, Rethanavelu K, Fung JLF, Wong RMS, Hui P, Yeung KS, Lo IFM, Chung BHY
Am J Med Genet A 2020 Jun;182(6):1329-1335. Epub 2020 Mar 21 doi: 10.1002/ajmg.a.61567. PMID: 32198975
Management of pregnancy in women with acquired and congenital heart disease.
Bowater SE, Thorne SA
Postgrad Med J 2010 Feb;86(1012):100-5. doi: 10.1136/pgmj.2008.078030. PMID: 20145059

Recent clinical studies

Etiology

Dilated ascending aorta in the fetus.
Dumitrascu-Biris I, Zidere V, Vigneswaran T, Charakida M, Mathur S, Kametas N, Simpson J
Prenat Diagn 2021 Aug;41(9):1127-1133. Epub 2021 Jul 8 doi: 10.1002/pd.6007. PMID: 34212413
Root repair with aortic ring annuloplasty using the standard approach.
Youssefi P, Zacek P, Berrebi A, Czytrom D, Mankoubi L, Noghin M, Monin JL, Debauchez M, Lansac E
J Cardiovasc Surg (Torino) 2021 Feb;62(1):12-18. Epub 2020 Nov 13 doi: 10.23736/S0021-9509.20.11690-2. PMID: 33185078
Thoracic aortic aneurysm.
Salameh MJ, Black JH 3rd, Ratchford EV
Vasc Med 2018 Dec;23(6):573-578. Epub 2018 Oct 29 doi: 10.1177/1358863X18807760. PMID: 30370834
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.
Mulè G, Nardi E, Morreale M, Castiglia A, Geraci G, Altieri D, Cacciatore V, Schillaci M, Vaccaro F, Cottone S
Adv Exp Med Biol 2017;956:427-445. doi: 10.1007/5584_2016_86. PMID: 27873227
Approach to the dilated aortic root.
Boyer JK, Gutierrez F, Braverman AC
Curr Opin Cardiol 2004 Nov;19(6):563-9. doi: 10.1097/01.hco.0000139724.27066.e4. PMID: 15502499

Diagnosis

Dilated ascending aorta in the fetus.
Dumitrascu-Biris I, Zidere V, Vigneswaran T, Charakida M, Mathur S, Kametas N, Simpson J
Prenat Diagn 2021 Aug;41(9):1127-1133. Epub 2021 Jul 8 doi: 10.1002/pd.6007. PMID: 34212413
A Review of the Surgical Management of Aorto-ventricular Tunnels.
Chowdhury UK, Anderson RH, George N, Singh S, Sankhyan LK, Pradeep D, Chauhan A, Sengupta S, Vaswani P
World J Pediatr Congenit Heart Surg 2021 Jan;12(1):103-115. doi: 10.1177/2150135120954809. PMID: 33407031
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.
Mulè G, Nardi E, Morreale M, Castiglia A, Geraci G, Altieri D, Cacciatore V, Schillaci M, Vaccaro F, Cottone S
Adv Exp Med Biol 2017;956:427-445. doi: 10.1007/5584_2016_86. PMID: 27873227
Repair of dilated aortic root and sinotubular junction using a stabilizer ring.
Neragi-Miandoab S
Recent Pat Cardiovasc Drug Discov 2012 Aug;7(2):134-40. doi: 10.2174/157489012801227229. PMID: 22494027
Approach to the dilated aortic root.
Boyer JK, Gutierrez F, Braverman AC
Curr Opin Cardiol 2004 Nov;19(6):563-9. doi: 10.1097/01.hco.0000139724.27066.e4. PMID: 15502499

Therapy

Root repair with aortic ring annuloplasty using the standard approach.
Youssefi P, Zacek P, Berrebi A, Czytrom D, Mankoubi L, Noghin M, Monin JL, Debauchez M, Lansac E
J Cardiovasc Surg (Torino) 2021 Feb;62(1):12-18. Epub 2020 Nov 13 doi: 10.23736/S0021-9509.20.11690-2. PMID: 33185078
Aortic Root Dilation and Testosterone Use: Are They Associated?
Goitom B, Thom D, Emerson D, Henderson L, Grant JD, D'Attellis N
J Cardiothorac Vasc Anesth 2020 Dec;34(12):3395-3397. Epub 2020 May 15 doi: 10.1053/j.jvca.2020.05.003. PMID: 32507461
Alcohol Consumption and Aortic Root Dilatation: Insights from the Corinthia Study.
Oikonomou E, Lazaros G, Tsalamandris S, Vogiatzi G, Christoforatou E, Papakonstantinou M, Goliopoulou A, Tousouli M, Chasikidis C, Tousoulis D
Angiology 2019 Nov;70(10):969-977. Epub 2019 May 7 doi: 10.1177/0003319719848172. PMID: 31064194
Risk of Aortic Dissection in Pregnant Patients With the Marfan Syndrome.
Kuperstein R, Cahan T, Yoeli-Ullman R, Ben Zekry S, Shinfeld A, Simchen MJ
Am J Cardiol 2017 Jan 1;119(1):132-137. Epub 2016 Sep 30 doi: 10.1016/j.amjcard.2016.09.024. PMID: 27788933
Decreased Aortic Elasticity in Children With Marfan Syndrome or Loeys-Dietz Syndrome.
Akazawa Y, Motoki N, Tada A, Yamazaki S, Hachiya A, Matsuzaki S, Kamiya M, Nakamura T, Kosho T, Inaba Y
Circ J 2016 Oct 25;80(11):2369-2375. Epub 2016 Oct 13 doi: 10.1253/circj.CJ-16-0739. PMID: 27733734

Prognosis

Personalised external aortic root support for elective treatment of aortic root dilation in 200 patients.
Van Hoof L, Rega F, Golesworthy T, Verbrugghe P, Austin C, Takkenberg JJM, Pepper JR, Treasure T
Heart 2021 Nov;107(22):1790-1795. Epub 2021 Jul 29 doi: 10.1136/heartjnl-2021-319300. PMID: 34326135
Aortic Branch Aneurysms and Vascular Risk in Patients With Marfan Syndrome.
Lopez-Sainz A, Mila L, Rodriguez-Palomares J, Limeres J, Granato C, La Mura L, Sabaté A, Guala A, Gutiérrez L, Galian-Gay L, Sao-Aviles A, Bellmunt S, Rodriguez R, Cuellar-Calabria H, Roque A, Ferreira-González I, Evangelista A, Teixido-Tura G
J Am Coll Cardiol 2021 Jun 22;77(24):3005-3012. doi: 10.1016/j.jacc.2021.04.054. PMID: 34140103Free PMC Article
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.
Mulè G, Nardi E, Morreale M, Castiglia A, Geraci G, Altieri D, Cacciatore V, Schillaci M, Vaccaro F, Cottone S
Adv Exp Med Biol 2017;956:427-445. doi: 10.1007/5584_2016_86. PMID: 27873227
Dilated aortic root is related to a global aortic dilating diathesis.
Alegret JM, Calvo N, Ligero C, Palomares R, Millá L, Martín-Paredero V, Montero M, Joven J
J Vasc Surg 2010 Oct;52(4):867-71. doi: 10.1016/j.jvs.2010.04.073. PMID: 20619587
Approach to the dilated aortic root.
Boyer JK, Gutierrez F, Braverman AC
Curr Opin Cardiol 2004 Nov;19(6):563-9. doi: 10.1097/01.hco.0000139724.27066.e4. PMID: 15502499

Clinical prediction guides

Aortic dissection during endurance cycling.
Murphy M
BMJ Case Rep 2023 Nov 17;16(11) doi: 10.1136/bcr-2023-257207. PMID: 37977829Free PMC Article
Personalised external aortic root support for elective treatment of aortic root dilation in 200 patients.
Van Hoof L, Rega F, Golesworthy T, Verbrugghe P, Austin C, Takkenberg JJM, Pepper JR, Treasure T
Heart 2021 Nov;107(22):1790-1795. Epub 2021 Jul 29 doi: 10.1136/heartjnl-2021-319300. PMID: 34326135
Isolated aortic root dilation in homocystinuria.
Lorenzini M, Guha N, Davison JE, Pitcher A, Pandya B, Kemp H, Lachmann R, Elliott PM, Murphy E
J Inherit Metab Dis 2018 Jan;41(1):109-115. Epub 2017 Oct 4 doi: 10.1007/s10545-017-0094-7. PMID: 28980096Free PMC Article
The Relationship Between Aortic Root Size and Hypertension: An Unsolved Conundrum.
Mulè G, Nardi E, Morreale M, Castiglia A, Geraci G, Altieri D, Cacciatore V, Schillaci M, Vaccaro F, Cottone S
Adv Exp Med Biol 2017;956:427-445. doi: 10.1007/5584_2016_86. PMID: 27873227
Approach to the dilated aortic root.
Boyer JK, Gutierrez F, Braverman AC
Curr Opin Cardiol 2004 Nov;19(6):563-9. doi: 10.1097/01.hco.0000139724.27066.e4. PMID: 15502499

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